Obesity Trials

Bariatrics

This trial examined three common types of bariatric surgeries: gastric bypass, adjustable gastric banding, and sleeve gastrectomy. The use of bariatric surgery to treat severe obesity has increased over the past 20 years, but there is still inadequate evidence about the benefits, complications, potential risks, and other outcomes associated with each procedure. This is especially true for adolescents.

This two-year observational study addressed three specific objectives:

  • Compare how patients’ weight loss and regain differs across the three bariatric surgical procedures
  • Compare rates of diabetes improvements or relapse over time after surgery
  • Research the frequency of complications or harms following these procedures
  • At this time, 3 manuscripts are in publication based on the results of this study. Links will be shared when available.

Antibiotics

The PCORnet study on childhood obesity looked at the relationship between antibiotic use in the first two years of life and weight gain in later childhood.

This observational study addressed three specific objectives:

  • Compare the effects of different types, timing, and amount of antibiotics used in the first two years of life with Body Mass Index (BMI) and obesity at ages 5 and 10
  • Compare the effects of antibiotic use on rates and patterns of children’s growth during their first 5 years of life
  • Explore how different factors such as gender, race and ethnicity, geographical location, or characteristics of the mother such as BMI or type of delivery, may impact outcomes

CAPriCORN participated in these two trials as a part of a national study under PCORnet. To find out more information about these trials, visit http://pcornet.org/obesity-studies-addressing-questions-treatment-prevention/.